Synergistic activities of methanol leave extracts of Acalypha wilkesiana, Senna alata, Psidium guajava against selected resistant bacteria isolates

Resistant strains of bacteria has over the years rendered conventional antibiotics ineffective. Consequently, this resulted to severe infection, prolonged treatment, high cost treatment and often times death. This study aimed identify reliable alternative sources bioactive agents with activity against resistant Staphylococcus aureus, Escherichia coli Salmonella typhi. Methanol extracts Acalypha wilkesiana (MEAW), Senna alata (MESA) Psidium guajava (MEPG) were tested alone in combination three clinical isolates. Ciprofloxacin was used as positive control drug. A Microscopic, macroscopic molecular protocols test The antibiotic profiles isolates E. (E1), S. aureus (S4) typhi (St2) indicated MultiDrug-Resisitant status (MDR). All demonstrated antibacterial zones inhibition that ranged between 3.1 – 25 mm minimum inhibitory concentration 12.5 200 mg/ml. Amongst tested, MESA found be most active extract while MEPG least extract. different methanol synergistic effects organisms a fractional 0.06 0.8 observed may linked presence some components such phenolic compounds flavonoids present extracts. results suggest A. wilkesiana, P. represent important for new drug development.